This page keeps track of new/upcoming treatment options for chronic migraine and headache disorders. What’s in development? What’s promising? What’s available soon? Find out below… Current topics include AXS-07, LAT8881, lasmiditan, DFN-15, vazegepant, ubrogepant, CGRP antibodies, Nerivio, neuromodulation, tDCS, DFN-02, and more.
Last updated: 4 years ago
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News
- Theranica Reports Positive Study Results of Nerivio (Neuromodulation) for Chronic Migraine Patients Jul 15, 2020
- Celecoxib Oral Solution Approved for Acute Migraine Treatment May 8, 2020
- Dr. Reddy’s Laboratories Receives FDA Approval for ELYXYB™ (celecoxib oral solution) in the U.S. for Acute Treatment of Migraine with or without Aura May 6, 2020
- Novel Therapy May Help Reduce Acute Migraine Medication Use Apr 30, 2020
- Research: Low-dose riboflavin is safe and modestly effective for migraines in children Apr 23, 2020
- AXS-07 effective against migraine pain in phase 3 INTERCEPT trial Apr 16, 2020
- Catalent Partners with Biohaven on New Fast-Dissolve Migraine Treatment Mar 17, 2020
- Lundbeck’s Vyepti Wins Approval for Preventative Treatment of Migraines Feb 24, 2020
- New migraine medication given the green light: Reyvow is a new prescription medication that was recently approved by the DEA Feb 15, 2020
- Lilly’s REYVOW (lasmiditan) C-V, the First and Only Medicine in a New Class of Acute Treatment for Migraine (ditan), Now Available for Prescription Jan 31, 2020
- New Migraine Treatment Relieves Pain In As Little As 2 Hours Dec 24, 2019
- FDA approves new drug to treat migraines Dec 23, 2019
- Lasmiditan: New first-in-class drug treatment approved for migraine Dec 18, 2019
- Biohaven Pharma says treatment for acute migraine (vazegepant) succeeds in study Dec 17, 2019
- New Devices And Advancements Being Used To Fight Migraines Dec 12, 2019
- CNN: New drug to fight migraine shows promise Nov 19, 2019
- Rapid Onset of Effect of Galcanezumab for the Prevention of Episodic Migraine Nov 11, 2019
- American Headache Society Publishes Article Demonstrating the Promise of Remote Electrical Neuromodulation (REN) as First-Line Treatment for Acute Migraine Relief Nov 8, 2019
- Interim Trial Results Show Lasmiditan Is Well Tolerated in Migraine Treatment Sep 20, 2019
- Teva to Present New Analyses of Fremanezumab Efficacy and Safety in Adult Patients with Difficult-to-Treat Migraine at 19th Congress of the International Headache Society Sep 3, 2019
- The New Era Of Disease Modifying Migraine Drugs (DMMDs) Sep 1, 2019
- Cannabis for the Prophylactic Treatment of Migraine: a Randomized Double-Blind Placebo-Controlled Clinical Trial Jun 5, 2019
- Once-a-month injection [Erenumab] offers hope to migraine patients May 18, 2019
- Bidirectional Association Between Migraine and Fibromyalgia May 2, 2019
- New treatment [CGRP blockers] offers promise of relief for migraine sufferers May 2, 2019
- Lilly to Present New Data at AAN 2019 on Emgality (galcanezumab-gnlm) and Lasmiditan Reinforcing Breadth of Headache Disorders Portfolio May 2, 2019
- Study Calls for “More Effective” Prophylactic Treatments for Migraine Apr 25, 2019
- Teva stops testing its migraine drug as cluster headache treatment Apr 23, 2019
- Life-changing drug (erenumab) for chronic migraine approved in Scotland Apr 8, 2019
- FDA Issues CRL for Rizaport Acute Migraine Treatment Apr 2, 2019
- New migraine-associated mechanism discovered Mar 29, 2019
- Why the sexes don’t feel pain the same way – “Modern anti-CGRP medicines might work better in women than in men” Mar 27, 2019
- Certain Visual Phenomena Linked to Headache and Migraine Mar 22, 2019
- OnabotulinumtoxinA (Botox) Effective in Real-World Settings to Prevent Migraine, Study Says Mar 21, 2019
- Theranica raises $35m Series B for neuromod migraine patch Mar 19, 2019
- Research team discovers link between sodium and migraines before pain occurs Mar 18, 2019
- Migraine Treatment Startup Theranica, developer of electrical nerve stimulation (ENS) technology for controlling migraines, Raises $35 Million Mar 18, 2019
- Biohaven Announces Completion of Pre-NDA Meeting With FDA for Oral CGRP Receptor Antagonist Rimegepant, “novel and differentiated treatment option to patients suffering from migraine” Mar 13, 2019
- Allergan Announces FDA Acceptance of New Drug Application for Ubrogepant for the Acute Treatment of Migraine Mar 11, 2019
- NDA for Novel Migraine Treatment Ubrogepant Accepted for FDA Review Mar 11, 2019
- How animal models are helping us understand migraine and cluster headache symptoms Mar 7, 2019
- Priority Review Granted for Treatment of Episodic Cluster Headache in Adults Mar 6, 2019
- Lilly Receives FDA Priority Review Designation for Emgality (galcanezumab-gnlm) Injection for the Preventive Treatment of Episodic Cluster Headache in Adults Mar 5, 2019
- Non-Invasive Device Gets FDA Clearance for Migraine Treatment, Prevention in Younger Patients Feb 28, 2019
- Non-invasive migraine treatment provides ‘instant’ relief for Plum woman Feb 25, 2019
- Tosymra Approved for the Acute Treatment of Migraine Feb 13, 2019
- What’s Next for Migraine Treatment – University of Utah Health Feb 11, 2019
Research
- The Efficacy and Safety of DFN-15 for the Treatment of Migraine: A Meta-Analysis of Randomized Controlled Studies Jul 14, 2020
- Therapeutic Implications of Altered Energy Metabolism in Migraine: A State-of-the-Art Review Jun 12, 2020
- Current Status at Drug Delivery Approaches and Assay of Anti-Migraine Drugs May 7, 2020
- Ketamine for Migraine in the Emergency Department: currently it is premature to incorporate ketamine into routine use May 2, 2020
- Effectiveness of low-dose riboflavin as a prophylactic agent in pediatric migraine Apr 23, 2020
- Potential for treatment benefit of small molecule CGRP receptor antagonist plus monoclonal antibody in migraine therapy Jan 13, 2020
- Mechanisms of migraine as a chronic evolutive condition Dec 23, 2019
- The influence of metoclopramide on trigeminovascular nociception: possible anti-migraine mechanism of action Nov 27, 2019
- Rapid Onset of Effect of Galcanezumab for the Prevention of Episodic Migraine Nov 11, 2019
- Cinnarizine and sodium valproate as the preventive agents of pediatric migraine Nov 10, 2019
- The Role of Magnesium in Pathophysiology and Migraine Treatment Nov 5, 2019
- Remote Electrical Neuromodulation (REN) for the Acute Treatment of Migraine Nov 5, 2019
- Integrating Pathophysiology in Migraine: Role of the Gut Microbiome and Melatonin Sep 20, 2019
- Trigeminal-Targeted Treatments in Migraine: Is 60% the Magic Number? Sep 11, 2019
- Efficacy of metoclopramide for the treatment of acute migraine Sep 9, 2019
- Memantine Ameliorates Migraine Headache Sep 1, 2019
- Gut Microbiota Dysbiosis Enhances Migraine-Like Pain Via TNFα Upregulation Aug 4, 2019
- Network Meta-Analysis of Calcitonin Gene-Related Peptide Receptor Antagonists for the Acute Treatment of Migraine Jul 12, 2019
- Efficacy of Anise (Pimpinella anisum L.) oil for migraine headache May 23, 2019
- Long-Term Safety and Tolerability of OnabotulinumtoxinA Treatment in Patients with Chronic Migraine: Results of the COMPEL Study May 17, 2019
- Fremanezumab as a preventive treatment for episodic and chronic migraine May 1, 2019
- Zonisamide appears to be an effective prophylactic treatment for patients with chronic and episodic cluster headache disorders Apr 30, 2019
- The effect of orofacial complete Freund’s adjuvant treatment on the expression of migraine-related molecules Apr 29, 2019
- Female versus male migraine: an event-related potential study of visual neurocognitive processing Apr 23, 2019
- Effect of adjunctive intermittent theta-burst repetitive transcranial magnetic stimulation as a prophylactic treatment in migraine patients – “safe and effective in reducing the frequency, duration, and severity of migraine headache” Apr 18, 2019
- Therapeutic novelties in migraine: new drugs, new hope? “Collectively, novel migraine therapies represent a major progress in migraine treatment and will undoubtedly transform headache medicine.” Apr 17, 2019
- Pathophysiological Mechanisms in Migraine and the Identification of New Therapeutic Targets Apr 15, 2019
- Once-monthly galcanezumab for the prevention of migraine in adults: an evidence-based descriptive review and potential place in therapy Apr 11, 2019
- Potential Protective Mechanisms of Ketone Bodies in Migraine Prevention Apr 10, 2019
- TRP Channels and Migraine: Recent Developments and New Therapeutic Opportunities Apr 9, 2019
- New Trends in Migraine Pharmacology: Targeting Calcitonin Gene-Related Peptide (CGRP) With Monoclonal Antibodies Apr 9, 2019
- How much do calcitonin gene-related peptide monoclonal antibodies improve the quality of life in migraine? Apr 3, 2019
- The discovery and development of inhaled therapeutics for migraine Mar 29, 2019
- A new era for migraine: Pharmacokinetic and pharmacodynamic insights into monoclonal antibodies with a focus on galcanezumab, an anti-CGRP antibody Mar 27, 2019
- Wet Cupping Reduces Pain and Improves Health-related Quality of Life Among Patients with Migraine: A Prospective Observational Study Mar 26, 2019
- The Connection Between Patent Foramen Ovale and Migraine – “migraine, especially migraine with aura, may be triggered by hypoxemia or vasoactive chemicals (eg, serotonin), which are ordinarily metabolized during passage through the lungs … PFO closure is currently not a FDA-approved therapy for migraines, randomized trials suggest that this intervention may benefit a subgroup of migraineurs” Mar 26, 2019
- Histamine and migraine revisited: mechanisms and possible drug targets – “Central H3 receptors seem to have a role in migraine that merit further investigation. The histaminergic system may be a goal for novel migraine drugs.” Mar 25, 2019
- Atypical functional connectivity between the anterior cingulate cortex and other brain regions in a Rat Model of Recurrent Headache – “Brain areas important for memory function may be related to the chronification of migraine. Electrophysiological studies should examine those migraine-related areas and provide new targets for migraine treatment and prevention.” Mar 22, 2019
- The THINK (Treatment of Headache with Intranasal Ketamine) Trial: A Randomized Controlled Trial Comparing Intranasal Ketamine with Intravenous Metoclopramide. Mar 22, 2019
- Emerging treatments for cluster headache: hopes and disappointments Mar 19, 2019
- Other Preventive Anti-Migraine Treatments: ACE Inhibitors, ARBs, Calcium Channel Blockers, Serotonin Antagonists, and NMDA Receptor Antagonists Mar 18, 2019
- Current Status of Antiepileptic Drugs as Preventive Migraine Therapy – “The potential role for new extended-release formulations of topiramate in migraine prevention is discussed. There is substantial evidence supporting the use of AEDs in migraine prevention.” Mar 18, 2019
- Alkaloids from the rhizomes of Ligusticum striatum exert antimigraine effects through regulating 5-HT1B receptor and c-Jun Mar 14, 2019
- CGRP Antagonists for the Treatment of Chronic Migraines: a Comprehensive Review – “CGRP antagonists appear to significantly improve treatment outcomes in patients who suffer from episodic and chronic migraines.” Mar 14, 2019
- The endocannabinoid system in migraine: an interesting area of research worth exploration in the quest for therapeutic targets Mar 14, 2019
- The Effectiveness of Acupuncture Combined with Tuina Therapy in Patients with Migraine Mar 14, 2019
- CGRP and migraine from a cardiovascular point of view: what do we expect from blocking CGRP? – “preventive treatment with CGRP antibodies has shown no relevant cardiovascular side effects” Mar 12, 2019
- DFN-02, Sumatriptan 10 mg Nasal Spray with Permeation Enhancer, for the Acute Treatment of Migraine – “DFN-02 was superior to placebo for the relief of migraine-related functional disability” Mar 12, 2019
- Study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of headache – “The herbal supplement significantly reduced the frequency of headaches in tension-type headache patients during treatment period … and the efficacy was maintained after 16 weeks of treatment withdrawal” Mar 12, 2019
- Ear acupuncture in the prophylactic treatment of chronic migraine Mar 11, 2019
- Electroacupuncture exerts an anti-migraine effect via modulation of the 5-HT7 receptor in the conscious rat Mar 7, 2019
- An open-label prospective study of the real-life use of onabotulinumtoxinA for the treatment of chronic migraine Mar 7, 2019
- Binaural stimulation in migraine: preliminary results from a 3-month evening treatment Mar 6, 2019
- Radiofrequency Ablation for Treating Headache Mar 4, 2019
- Prediction of patient’s response to OnabotulinumtoxinA treatment for migraine Feb 28, 2019
- Extracranial Trigger Site Surgery for Migraine: A Systematic Review With Meta-Analysis on Elimination of Headache Symptoms Feb 14, 2019
- Relating Photophobia, Visual Aura, and Visual Triggers of Headache and Migraine Feb 8, 2019
- Acupuncture for the prevention of episodic migraine Feb 7, 2019
- CGRP antibodies for migraine prevention — new kids on the block Feb 1, 2019
- Behavioral and cognitive animal models in headache research Jan 31, 2019
- Efficacy of ADAM Zolmitriptan for the Acute Treatment of Difficult‐to‐Treat Migraine Headaches Jan 30, 2019
- Getting closer to a cure for migraine Jan 17, 2019
- Efficacy and safety of exogenous ketone bodies for preventive treatment of migraine: A study protocol Jan 17, 2019
- Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK Jan 16, 2019
- Dynamic changes in CGRP, PACAP, and PACAP receptors in the trigeminovascular system of a novel repetitive electrical stimulation rat model: Relevant to migraine Jan 14, 2019
- Phytomedicines in the Treatment of Migraine Jan 9, 2019
- Can Functional Nasal Surgery Treat Chronic Headaches? Dec 1, 2018
- Beta Blocker Eye Drops Have Dramatically Helped My Severe Migraines Dec 1, 2018
- Efficacy of CoQ10 as supplementation for migraine: A meta-analysis Nov 14, 2018
- Long-chain omega-3 fatty acids and headache in the U.S. population – “higher dietary intakes of EPA and DHA were associated with lower prevalence of headache” Jul 12, 2018
- CGRP in Human Models of Migraine Jun 13, 2018
- MiR-30a relieves migraine by degrading CALCA Apr 26, 2018
- Recent Advances in Pharmacotherapy for Migraine Prevention: From Pathophysiology to New Drugs Feb 2, 2018
Clinical Trials
- A Study to Test if Fremanezumab is Effective in Preventing Chronic Migraine in Patients 6 to 17 Years of Age Jul 9, 2020
- Efficacy and Safety of Rizatriptan-Naproxen (10/550 mg) in the Acute Treatment of Migraine May 13, 2020
- Cannabis for Acute Migraine: a Randomized, Double-blind, Placebo-controlled, Crossover Trial Apr 24, 2020
- A Safety Evaluation Trial of TEV-48125 Self-administered in Migraine Patients Apr 21, 2020
- Efficacy and Safety of Nerivio™, a Remote Electrical Neuromodulation Device, for Acute Treatment of Migraine in People With Chronic Migraine Nov 13, 2019
- A Proof of Concept Study of the Efficacy and Safety of Oral LAT8881 in Acute Migraine Nov 6, 2019
- Safety and Efficacy of Nerivio™ for the Acute Treatment of Migraine in Adolescents Sep 17, 2019
- Open-Label Long-Term Safety Study of AXS-07 for the Acute Treatment of Migraine Aug 26, 2019
- A Study of Home-Delivered Neurostimulation for Migraine Aug 14, 2019
- Cannabis for the Prophylactic Treatment of Migraine: a Randomized Double-Blind Placebo-Controlled Clinical Trial Jun 5, 2019
- Study of Sustained Benefit of Erenumab in Adult Episodic Migraine Patients Apr 25, 2019
- Saline Injections for Prophylactic Treatment of Chronic Migraine Apr 18, 2019
- Optical Treatment of Migraines Using the Avulux Optical Filter in the Form of Spectacle Lenses Apr 4, 2019
- Peripheral Electrical Stimulation for Migraine Prevention Apr 3, 2019
- A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate STS101 in the Acute Treatment of Migraine Apr 3, 2019
- Ketamine for Refractory Chronic Migraine: a Pilot Study Mar 29, 2019
- MOMENTUM: A Randomized, Double-blind, Single-dose, Placebo-controlled Study to Assess the Efficacy and Safety of AXS-07 (Meloxicam and Rizatriptan) for the Acute Treatment of Migraine in Adults Mar 29, 2019
- Efficacy of a Transcranial Vibrating System for Mitigation of Migraine Associated Vertigo Mar 22, 2019
- The Effects of Maxipost (BMS 204352) on Cerebral Hemodynamic and Headache in Healthy Volunteers and Migraine Patients Mar 22, 2019
- Valproic Acid and Dihydroergotamine in the treatment of pediatric migraines Mar 21, 2019
- A Study to Assess the Efficacy and Safety of Oral CL-H1T in the Treatment of Acute Migraine Pain Mar 18, 2019
- Study to Determine Safety and Efficacy of B244 in Subjects With Episodic Migraine Mar 15, 2019
- Bioavailability of DHE Administered by I123 POD Device, IV Injection, and Migranal Nasal Spray in Healthy Adults Mar 15, 2019
- A Phase I Study to Study the PK and Safety of Single Doses of STS101, DHE Injection and Nasal Spray in Healthy Subjects Mar 14, 2019
- A Study of Home-Delivered Neurostimulation for Migraine Mar 14, 2019
- Long-term Safety and Tolerability of Subcutaneous Administration of TEV-48125 for the Preventive Treatment of Migraine Mar 13, 2019
- A Safety and Efficacy Study to Evaluate AMG 334 in Migraine Prevention Mar 13, 2019
- Acute Treatment Trial in Adult Subjects With Migraines Mar 13, 2019
- Effects of Aromatherapy on the Headache and Service Quality Among Nurses Working in Critical Care Nurses Units Mar 8, 2019
- To Evaluate the Safety and Tolerability of Treatment With Atogepant 60 mg Daily for the Prevention of Migraine in Participants With Episodic Migraine Mar 8, 2019
- Study to Assess the Safety and Efficacy of ONZETRA® Xsail® (Sumatriptan Nasal Powder) for the Acute Treatment of Episodic Migraine With or Without Aura in Adolescents Mar 7, 2019
- Study of Efficacy and Safety of Erenumab in Adult Chronic Migraine Patients Mar 7, 2019
- Objectively Diagnose and Monitor Treatment of Light Sensitivity Mar 6, 2019
- Study of Efficacy and Safety of AMG 334 in Adult Episodic Migraine Patients (EMPOwER) Feb 26, 2019
- A Multicenter, Open Label Long-Term Safety Study of BHV3000 in the Acute Treatment of Migraine Jan 24, 2019
